Antihypertensive (blood Pressure Lowering) Effects of Stevioside, from Stevia Rebaudiana Bertoni, on Rats, Dogs and Humans – a Short Review
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چکیده
ANTIHYPERTENSIVE (BLOOD PRESSURE LOWERING) EFFECTS OF STEVIOSIDE, FROM STEVIA REBAUDIANA BERTONI, ON RATS, DOGS AND HUMANS – A SHORT REVIEW HIMANSHU MISRA1,2*, DARSHANA MEHTA1, B. K. MEHTA1* and D. C. JAIN2 1Natural Products Research Laboratory, School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain-456 010, Madhya Pradesh, India. 2Green Technology Department, Ipca Laboratories Limited, Ratlam-457 001, Madhya Pradesh, India. For Correspondence: Natural Products Research Laboratory, School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain-456 010, Madhya Pradesh, India. ABSTRACT Here, we have reviewed antihypertensive (blood pressure lowering) effects of a natural, zero-calorie sweetener–‘stevioside’ (from the leaves of Stevia rebaudiana Bertoni) on rats, dogs and humans. The review of the medicative effects of stevioside on different animals (rats and dogs) and humans revealed that stevioside is a future plant drug (natural product) for treatment of hypertension.
منابع مشابه
Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat.
Stevioside, a glycoside present in the leaves of the plant, Stevia rebaudiana Bertoni (SrB), has acute insulinotropic effects in vitro. Its potential antihyperglycemic and blood pressure-lowering effects were examined in a long-term study in the type 2 diabetic Goto-Kakizaki (GK) rat. Rats were fed 0.025 g x kg(-1) x d(-1) of stevioside (purity > 99.6%) for 6 weeks. An intra-arterial catheter w...
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